Dapagliflozin

Why You May Be Offered Dapagliflozin

If you are living with type 2 diabetes and have some level of reduced kidney function,there is evidence a new medication called dapagliflozin can help protect your renal health.

This is a treatment that not only helps manage your blood sugar levels but also has proven benefits for kidney health and heart protection.

What is Dapagliflozin?

Dapagliflozin (brand name Forxiga) is a medicine from a group of drugs called SGLT2 inhibitors. It works in the kidneys to help remove excess sugar from your body through your urine. But its benefits go beyond just blood sugar control.

Why Has This Been Recommended?

You may be offered dapagliflozin if you:

• Have type 2 diabetes

• Show signs of reduced kidney function (even mild to moderate)

• Are at risk of further kidney damage or heart complications

Research has shown that dapagliflozin can slow the progression of kidney disease and reduce the risk of heart failure and cardiovascular events — even in people with relatively early signs of kidney problems.

How Does It Work?

Dapagliflozin:

• Helps your kidneys remove excess glucose (sugar) via urine

• Reduces pressure in the kidneys, helping protect them over time

• Can lower blood pressure slightly and help with weight management

• Reduces the strain on the heart, helping to prevent heart failure

What Are the Potential Benefits?

By taking dapagliflozin, you may experience:

✅ Better blood sugar control
✅ Slower decline in kidney function
✅ Reduced risk of needing dialysis or kidney replacement therapy
✅ Lower risk of hospitalisation for heart failure
✅ Possible weight loss and slight blood pressure reduction

These benefits can happen even if your blood sugar is already well controlled with other medications.

Are There Any Side Effects?

Like all medicines, dapagliflozin can have some side effects. Most people tolerate it well, but it’s good to be aware of the following:

• Increased urination – because more sugar and water are passed in your urine

• Genital infections (thrush) – more common in both men and women, especially if you’ve had them before

• Urinary tract infections (UTIs) – less common, but possible

• Dehydration – due to fluid loss, especially in hot weather or if unwell

• Rarely: diabetic ketoacidosis (DKA) – a serious condition. This is more common in people with type 1 diabetes but can occur in type 2. Let your doctor know if you feel sick, vomit, or have stomach pain.

Important: Let your GP know if you become unwell (especially with vomiting or dehydration) or are due for surgery – you may be advised to stop the medication temporarily.

How Will I Be Monitored?

Before and during your treatment, your GP or practice nurse will check:

• Kidney function (blood and urine tests)

• HbA1c (a measure of your blood sugar control)

• Blood pressure and weight